发明名称 Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
摘要 Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.
申请公布号 US8148377(B2) 申请公布日期 2012.04.03
申请号 US20080069667 申请日期 2008.02.11
申请人 COOK ROBERT O.;SHREWSBURY STEPHEN B.;RAMADAN NABIH N.;ARMER THOMAS A.;MAP PHARMACEUTICALS, INC. 发明人 COOK ROBERT O.;SHREWSBURY STEPHEN B.;RAMADAN NABIH N.;ARMER THOMAS A.
分类号 A61K31/48 主分类号 A61K31/48
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