发明名称 |
Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand |
摘要 |
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia. |
申请公布号 |
US8147844(B1) |
申请公布日期 |
2012.04.03 |
申请号 |
US19940374540 |
申请日期 |
1994.12.28 |
申请人 |
EATON DAN L.;DE SAUVAGE FREDERIC J.;GENENTECH, INC. |
发明人 |
EATON DAN L.;DE SAUVAGE FREDERIC J. |
分类号 |
C07H21/04;A61K38/00;A61K38/19;C07K14/52;C12N15/12;C12N15/19 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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