| 发明名称 |
Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
| 摘要 |
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product. |
| 申请公布号 |
US8148105(B2) |
申请公布日期 |
2012.04.03 |
| 申请号 |
US20080531037 |
申请日期 |
2008.03.14 |
| 申请人 |
VORA HARMIT;MCINTIRE JAMES;KUMAR PAWAN;KHOSLA CHAITAN;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;ALVINE PHARMACEUTICALS, INC. |
发明人 |
VORA HARMIT;MCINTIRE JAMES;KUMAR PAWAN;KHOSLA CHAITAN |
| 分类号 |
C12N15/09;C07K1/14;C07K1/22;C12N9/50;C12N15/29;C12N15/57 |
主分类号 |
C12N15/09 |
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