发明名称 |
NOVEL FORMS OF CDDO METHYL ESTER ALSO KNOWN AS METHYL 2-CYANO-3,12-DIOXOLEANA-1,9(11)-DIEN-28 OATE |
摘要 |
Disclosed is a glassy solid form of CDDO-methyl ester (also known as methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate as depicted in the drawing of figure 1), having an x-ray powder diffraction pattern with a halo peak at approximately 13.5 degrees 2 theta, as shown in Figure 2C in the specification, and a Tg. Also disclosed is a pharmaceutical composition comprising (i) a therapeutically effective amount of CDDO-methyl ester and (ii) an excipient that is a glass former, such that said composition has a Tg. Further disclosed is a pharmaceutical composition comprising the glassy solid form of CDDO methyl ester and the use of the pharmaceutical composition in the manufacture of a medicament for the treatment of cancer.
|
申请公布号 |
NZ583269(A) |
申请公布日期 |
2012.03.30 |
申请号 |
NZ20080583269 |
申请日期 |
2008.08.14 |
申请人 |
REATA PHARMACEUTICALS, INC. |
发明人 |
WALLING, JOHN;PARENT, STEPHAN, D;JONAITIS, DAVID, T;KRAL |
分类号 |
A01N43/04;A61K31/70;A61P35/00;C07C15/20 |
主分类号 |
A01N43/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|