Human monoclonal antibodies to CD70

摘要

Disclosed is an isolated monoclonal antibody or antigen binding portion thereof comprising: a) a heavy chain variable region CDR1 comprising SEQ ID NO: 11; b) a heavy chain variable region CDR2 comprising SEQ ID NO: 16; c) a heavy chain variable region CDR3 comprising SEQ ID NO: 21; d) a light chain variable region CDR1 comprising SEQ ID NO: 26; e) a light chain variable region CDR2 comprising SEQ ID NO: 31; and f) a light chain variable region CDR3 comprising SEQ ID NO: 36. Also disclosed is the use of the antibody for the preparation of a medicament for the treatment or prevention of a disease characterized by growth of tumor cells expressing CD70 in a subject.