摘要 |
A compound of Formula enantiomers, diasteriomers, tautomers or pharmaceuticallyacceptable sails thereof, wherein RI, R2, R3, R: and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed. Formula (l).R2 No available figure |
申请人 |
GENENTECH, INC. |
发明人 |
ZHU, BING-YAN;SIU, MICHAEL;MAGNUSON, STEVEN, R.;PASTOR, RICHARD;HAIYING, HE;YISONG, XIAO;JIFU, ZHENG;XING, XU;JUNPING, ZHAO;JOSEPH P. LYSSIKATOS;HURLEY, CHRISTOPHER A.;LIU, WENDY;LIANG, JUN |