METHODS FOR INDUCTION, PREDICTIVE DIAGNOSIS, AND TREATMENT OF AFFECTIVE BEHAVIORS BY MODULATION OF PPAR AND RXR RECEPTORS

摘要

The present invention is directed to methods for modulating or detecting changes in peroxisome proliferator activated receptors (PPARs) and retinoid X receptors (RXR) to: 1) treat certain neuropsychiatric disorders, 2) identify susceptibility to such disorders in a clinical setting, and 3) screen novel pharmacological agents, including retinoids and retinoid derivatives for adverse psychiatric side-effects, and 4) generate certain neuropsychiatric disorders in preclinical conditions.