发明名称 |
METHODS FOR TREATING CANCERS AND DISEASES ASSOCIATED WITH 4-1BB (CD137) EXPRESSION |
摘要 |
The present invention relates to the role of 4-1BB (CD137) ligand and anti-4-1BB (CD137) antibody in the treatment of cancers and diseases associated with 4-1BB (CD137) expression. More particularly, the present invention relates to the use of (i) 4-1BB (CD137) ligand for inducing proliferation and activation and promoting survival of B lymphocytes and (2) anti-4-1BB (anti-CD137) antibody for inhibiting proliferation and activation and inducing death of B lymphocytes. |
申请公布号 |
US2012076722(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
US201013320267 |
申请日期 |
2010.05.11 |
申请人 |
STROME SCOTT;ZHANG XIAOYU;UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
STROME SCOTT;ZHANG XIAOYU |
分类号 |
A61K39/395;A61K38/17;A61K51/00;A61P37/04;C12Q1/68;G01N21/75;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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