发明名称 |
Methods for making Apo-2 Ligand using divalent metal ions |
摘要 |
Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis. |
申请公布号 |
US2012077740(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
US20100928422 |
申请日期 |
2010.12.10 |
申请人 |
ASHKENAZI AVI J.;HYMOWITZ SARAH;KELLEY ROBERT F.;KOUMENIS IPHIGENIA;LEUNG WOON-LAM SUSAN;O'CONNELL MARK;PAI ROGER;SHAHROKH ZAHRA;SIMMONS LAURA;GENENTECH, INC. |
发明人 |
ASHKENAZI AVI J.;HYMOWITZ SARAH;KELLEY ROBERT F.;KOUMENIS IPHIGENIA;LEUNG WOON-LAM SUSAN;O'CONNELL MARK;PAI ROGER;SHAHROKH ZAHRA;SIMMONS LAURA |
分类号 |
A61K38/19;B01J20/281;A61K9/00;A61K9/08;A61K9/19;A61K38/00;A61K47/02;A61P31/12;A61P35/00;B01D15/32;B01D15/36;B01J20/285;C07K1/14;C07K1/18;C07K1/20;C07K14/52;C07K14/525;C07K14/705;C12N1/21;C12N15/09;C12N15/19;C12N15/63;C12P21/02;C12R1/19;G01N30/88;G01N30/96 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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