The present invention refers to an alternative method for the preparation of Erlotinib through a new chemical reaction for the preparation of the 4-(3-aminophenyl)-2-methyl-3-butyn-2-ol key intermediate of formula (IV) according to the following scheme.
申请公布号
EP2433931(A1)
申请公布日期
2012.03.28
申请号
EP20110184698
申请日期
2011.10.11
申请人
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
发明人
CASTELLIN, ANDREA;DE LUCCHI, OTTORINO;CAPORALE, ANDREA
