| 摘要 |
The present invention relates to a magnetic hybrid hydrogel comprising a biocompatible, bioreabsorbable polymer crosslinked with magnetic particles which act as crosslinking agents. The polymer can be a polysaccharide chosen from among carboxymethyl cellulose, hyaluronic acid, chitin, alginic acid, alginates, chitosan or combinations thereof; or else a synthetic polymer chosen from among polyacrylic acid, polylactic acid, polyvinylamine or combinations thereof. The magnetic nanoparticles can be nanoparticles of Fe2C>3, Fe304, Fe204 or else mixed nanoparticles of Fe and Co, Mn or Zn, preferably functionalized with -NH2, - COOH,-OH,-SH groups. The hydrogel is used in oncological medicine for the targeted administration and controlled release of a drug, or else in regenerative medicine for applications of cells or other factors for the purpose of regenerating or repairing a tissue or organ. |
