| 摘要 |
<p>6-APA is acylated with D(-)alpha-aminophenylacetic acid protected by reaction with a beta-keto ester, a beta-dicarboxylic acid or O-nitrophenylsulphenyl chloride in an organic solvent at pH 8-10 at 20-80 degrees C. As the product hydrolysed in aq. acetone pref. at pH 2-3.5, evapd., the residue extd. with an organic solvent, pref. BuOAc and the title product (I) isolated. (I) is a broad spectrum anti-biotic and is produced by a simple procedure without isolation of intermediates.</p> |
