发明名称 |
POLYHYDROXY PHENOLS AND THEIR USE IN BINDING P-SELECTIN |
摘要 |
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.
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申请公布号 |
CA2527141(C) |
申请公布日期 |
2012.03.27 |
申请号 |
CA20042527141 |
申请日期 |
2004.05.07 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
BIESSEN, ERIK ANNA LEONARDUS;APPELDOORN, CHANTAL CATHARINA MARIA;BONNEFOY, ARNAUD;VAN BERKEL, THEODORUS JOSEPHUS CORNELIS;KUIPER, JOHAN;HOYLAERTS, MARC FLORIMOND |
分类号 |
C07C69/96;A61K9/107;A61K9/127;A61K31/198;A61K47/18;A61K47/48;C07C227/14;C07C229/16;C07C237/22;C07D209/20 |
主分类号 |
C07C69/96 |
代理机构 |
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地址 |
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