发明名称 |
PROLYL ENDOPEPTIDASE PROBES |
摘要 |
Prolyl endopeptidase (PE) activity in lung samples is detected by contacting the lung sample with a probe comprising a -P-X- (or -X-P-, -P-X-P-) PE recognition site, wherein P is a prolyl bioisostere, X is a residue that is not a prolyl bioisostere or is a prolyl bioisostere flanked on each side by a residue that is not a prolyl bioisostere, and "-" is an amide bond, under conditions wherein PE activity of the sample specifically hydrolyzes an amide bond of the recognition site to generate an optical signal; and (b) detecting the signal. |
申请公布号 |
CA2811107(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
CA20112811107 |
申请日期 |
2011.09.12 |
申请人 |
SRI INTERNATIONAL |
发明人 |
GALANDE, AMIT K.;WATSON, DOUGLAS STUART;KODUKULA, KRISHNA;JAMBUNATHAN, KALYANI |
分类号 |
G01N33/53;G01N33/52;G01N33/573 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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