BENZOYL PEROXIDE COMPOSITION, METHODS OF MAKING SAME, AND PHARMACEUTICAL OR COSMETIC FORMULATIONS COMPRISING SAME, AND USES THEREOF

摘要

The present invention relates to the preparation of compositions comprising benzoyl peroxide, with or without other additional active ingredients. The process involves introducing benzoyl peroxide, along with any other active ingredients present, into a fatty substance that contains and protects the ingredients that would otherwise be unstable when in contact with one another. The composition is designed to allow all ingredients to become available for skin contact or skin absorption when the fatty substance softens and/or melts as the composition is applied to the skin. The benzoyl peroxide may be pre-micronized to a particle distribution size of about dgo of 0.1 to 150 microns, preferably dgo of 10 to 15 microns.