发明名称 |
OMV (OUTER MEMBRANE VESICLE) VACCINES |
摘要 |
The invention is in the field of outer membrane vesicles (OMV) and their uses. More particularly the present invention provides OMV obtained from a bacterium being an ompA mutant and/or a mutant in one or more components of the Tol-Pal complex (TolR, TolA, TolB, Pal and/or TolQ) and presenting a heterologous antigen on its surface. The heterologous antigen is selected from the group consisting of Chlamydia trachomatis CT823, CT681, CT372, CT443, CT043, CT733, CT279, CT601 and CT153 for the treatment, prevention or diagnosis of Chlamydia infection. |
申请公布号 |
WO2011161551(A3) |
申请公布日期 |
2012.03.22 |
申请号 |
WO2011IB02341 |
申请日期 |
2011.06.10 |
申请人 |
NOVARTIS AG;GRIFANTINI, RENATA, MARIA;FINCO, ORETTA;BARTOLINI, ERIKA;GRANDI, GUIDO |
发明人 |
GRIFANTINI, RENATA, MARIA;FINCO, ORETTA;BARTOLINI, ERIKA;GRANDI, GUIDO |
分类号 |
C12N1/00;A61K39/116;A61K39/118;C07K14/295;C12P1/04 |
主分类号 |
C12N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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