发明名称 |
RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE |
摘要 |
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate. |
申请公布号 |
US2012071660(A1) |
申请公布日期 |
2012.03.22 |
申请号 |
US201013322575 |
申请日期 |
2010.05.27 |
申请人 |
COPMANS ALEX HERMAN;HOET JEROME ALBERT JOSEPH;WILLEMSEMS ALBERT LOUIS ANNA;COUCK WOUTER LOUIS J.;VAN DUN JOAANES PETRUS |
发明人 |
COPMANS ALEX HERMAN;HOET JEROME ALBERT JOSEPH;WILLEMSEMS ALBERT LOUIS ANNA;COUCK WOUTER LOUIS J.;VAN DUN JOAANES PETRUS |
分类号 |
C07D211/32 |
主分类号 |
C07D211/32 |
代理机构 |
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代理人 |
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地址 |
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