发明名称 |
Modulation of gene expression by oligomers targeted to chromosomal DNA |
摘要 |
<p>Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.</p> |
申请公布号 |
EP2431467(A2) |
申请公布日期 |
2012.03.21 |
申请号 |
EP20110002451 |
申请日期 |
2006.11.13 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
COREY, DAVID REID;SHAMES, DAVID S.;JANOWSKI, BETHANY A.;MINNA, JOHN D. |
分类号 |
C12N15/113;A61K48/00;C12N15/11;C12N15/12;C12N15/63 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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