URACYL SPIROOXETANE NUCLEOSIDES

摘要

Compounds of the formula I:
including any possible stereoisomers thereof, wherein:
R 4
is a monophosphate, diphosphate or triphosphate ester; or R 4 is
R 7
is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl;
R 8 and R 8'
are hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8' form C 3 -C 7 cycloalkyl;
R 9
is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, phenyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted;
or a pharmaceutically acceptable salt or solvate thereof;
pharmaceutical formulations and the use of compounds I as HCV inhibitors.