发明名称 |
Compounds for intracellular delivery of therapeutic moieties to nerve cells |
摘要 |
A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM. |
申请公布号 |
US8138155(B2) |
申请公布日期 |
2012.03.20 |
申请号 |
US20100749339 |
申请日期 |
2010.03.29 |
申请人 |
WEBB ROBERT R.;MCKEE CONSTANCE A.;MANZANITA PHARMACEUTICALS, INC. |
发明人 |
WEBB ROBERT R.;MCKEE CONSTANCE A. |
分类号 |
A61K38/18;A61K47/28;A61K47/30;A61K47/42;A61K47/48;A61P5/00;A61P25/00;A61P25/04;A61P31/12;C07K14/48 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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