<p>A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.</p>
申请公布号
WO2012034123(A1)
申请公布日期
2012.03.15
申请号
WO2011US51228
申请日期
2011.09.12
申请人
CORNELL UNIVERSITY;CERIONE, KRISTIN, WILSON;CERIONE, RICHARD, A.