发明名称 |
STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA |
摘要 |
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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申请公布号 |
US2012064077(A1) |
申请公布日期 |
2012.03.15 |
申请号 |
US201113245420 |
申请日期 |
2011.09.26 |
申请人 |
EWERT STEFAN;BARBERIS ALCIDE;URECH DAVID M.;AUF DER MAUR ADRIAN;LICHTLEN PETER;ESBATECH, AN ALCON BIOMEDICAL RESEARCH UNIT LLC. |
发明人 |
EWERT STEFAN;BARBERIS ALCIDE;URECH DAVID M.;AUF DER MAUR ADRIAN;LICHTLEN PETER |
分类号 |
A61K39/395;A61P1/00;A61P19/02;A61P27/02;A61P29/00;C07K16/24;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/63;C12P21/02;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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地址 |
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