MODIFIED RODENT PARVOVIRUS CAPABLE OF PROPAGATING AND SPREADING THROUGH HUMAN GLIOMAS
摘要
Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described.
申请公布号
WO2011138053(A3)
申请公布日期
2012.03.15
申请号
WO2011EP02306
申请日期
2011.05.09
申请人
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTES;NUEESCH, JUERG;THOMAS, NADJA;PLOTZKY, CLAUDIA;ROMMELAERE, JEAN
发明人
NUEESCH, JUERG;THOMAS, NADJA;PLOTZKY, CLAUDIA;ROMMELAERE, JEAN