| 发明名称 |
INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE |
| 摘要 |
Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein. |
| 申请公布号 |
US2012065200(A1) |
申请公布日期 |
2012.03.15 |
| 申请号 |
US201113231653 |
申请日期 |
2011.09.13 |
| 申请人 |
BARBOSA JOSEPH;CARSON KENNETH GORDON;GARDYAN MICHAEL WALTER;HE WEI;LOMBARDO VICTORIA;PABBA PRAVEEN;TARVER, JR. JAMES |
发明人 |
BARBOSA JOSEPH;CARSON KENNETH GORDON;GARDYAN MICHAEL WALTER;HE WEI;LOMBARDO VICTORIA;PABBA PRAVEEN;TARVER, JR. JAMES |
| 分类号 |
A61K31/519;A61K31/5377;A61P19/00;C07D495/04;C07D495/14 |
主分类号 |
A61K31/519 |
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