DETERMINATION OF ABCA1 PROTEIN LEVELS IN CELLS

摘要

The present invention refers to an assay method for determining the ability of compounds to modulate the level of ABCA1 protein in cells and its use in drug discovery and screening. The method is characterized by the use of apolipoprotein A-I labeled with a fluorophore for the detection of ABCA1 protein levels in cells and can be used for the detection of compounds being useful as HDL-cholesterol raising agents.