摘要 |
<p>Disclosed are compounds, which have excellent effects of inhibiting DGAT and suppressing food intake, or pharmacologically acceptable salts of the same. Specifically disclosed are 4-carboxymethyl-cyclohexyl trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinolin e-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, etc., or pharmacologically acceptable salts of the same.</p> |