Active siRNA-Inorganic Layered Double Hydroxide Nanohybrid, a Process for Preparing the Same, and a Pharmaceutical Composition Comprising the Same for Treating Targeted Tumor

摘要

PURPOSE: An siRNA-inorganic layered double hydroxide nanohybrid is provided to improve tumor-specific transfer efficiency. CONSTITUTION: An siRNA-inorganic layered double hydroxide nanohybrid is denoted by chemical formula 1(M(II)_1-Xm(III)_x(OH)_2]^X+[S][T]). In chemical formula 1, M(II) is bivalent metal cation, and M(III) is trivalent metal cation. The siRNA is derived from surviving gene. The siRNA is denoted by a base sequence selected from sequence numbers 1-9. A pharmaceutical composition for treating tumor contains the nanohybrid and pharmaceutically acceptable carrier. The composition is manufacture in the form of tablet, capsule, liquid, injection, ointment, or syrup.