发明名称 |
Modified reoviral therapy |
摘要 |
<p>The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.</p> |
申请公布号 |
AU2002335667(A1) |
申请公布日期 |
2003.02.17 |
申请号 |
AU20020335667 |
申请日期 |
2002.08.02 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
JEFFREY TARRAND;XIANG-YANG HAN |
分类号 |
A61K35/76;A61K47/48;A61P9/10;A61P19/02;A61P35/00;A61P43/00;C12N5/08;C12N5/22;C12N15/38;C12N15/46;(IPC1-7):A61K39/15;C12N7/00;A61K39/44;C12N7/04;C12N5/00;C12N13/00;A61K39/395 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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