TENOFOVIR DISOPROXIL FUMARATE a-CRYSTAL FORM, PREPARATION METHOD AND APPLICATION THEREOF

摘要

Tenofovir disoproxil fumarate a-crystal form, preparation method and application thereof are disclosed. By Cu-Ka radiation, an X-ray powder diffraction spectrum of tenofovir disoproxil fumarate a-crystal form, expressed in degrees 2T, shows characteristic peaks at about 7.1, 7.8, 8.1, 9.8, 10.5, 10.9, 1 1.6, 1 1.9, 13.7, 14.3, 14.7, 15.6, 16.1, 16.6, 16.8, 17.9, 18.4, 19.2, 20.4, 21.2, 21.6, 22.5, 22.7, 23.4, 24.3, 25.4 and 26.4. The prepared tenofovir disoproxil fumarate a-crystal form gets a visibly ad vantage over the former crystal form on the aspect of dissolution rate and has better absorption into the body. The preparation method is simple and adaptive for industrialized production.