发明名称 |
COMPOSITIONS, KITS, AND METHODS FOR PROMOTING ISCHEMIC AND DIABETIC WOUND HEALING |
摘要 |
Compositions, kits and methods for promoting diabetic wound healing are based on the discovery that SDF-1αspecifically upregulates expression of E-selectin in mature endothelial cells (EC), leading to an increase in EC-endothelial progenitor cell (EPC) adhesion and EPC homing. Methods for promoting healing of a wound in a diabetic subject include providing a therapeutically effective amount of a composition including E-selectin protein or a nucleic acid encoding E-selectin protein, and optionally, an agent that specifically upregulates E-selectin expression (e.g., SDF-1α). The methods can also include administering hyperbaric oxygen treatment to the subject. Administering the composition to the subject results in migration of bone marrow-derived progenitor cells to the wound, accelerated wound healing, and upregulation of E-selectin expression in the subject.
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申请公布号 |
US2012058086(A1) |
申请公布日期 |
2012.03.08 |
申请号 |
US201013138889 |
申请日期 |
2010.04.09 |
申请人 |
VELAZQUEZ OMAIDA C.;LIU ZHAO-JUN |
发明人 |
VELAZQUEZ OMAIDA C.;LIU ZHAO-JUN |
分类号 |
A61K38/19;A61K33/00;A61K35/76;A61K38/17;A61K48/00;A61P17/02 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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地址 |
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