摘要 |
New spiro compds I [R=H, alkyl; X=H, Cl, Br, iodo, alkyl, di-Me, (un) substd. phenylalkyl; Z,Y=H, halo, No2, CF3, alkoxy, alkyl; W=CO, CHOH; U=O, S, NH; n=0,1! and their salts were prepd. Thus, spiro[imidazolidine-4,1'-indan!-2,5-dione was refluxed with CF3CON(SiMe3)2 and Br in CHCl3 for 18h followed by treating with H2O to give 3'-hydroxyspiro[imidazolidine-4,1'-indan!-2,5-dione. Cpds I are useful for treating chronic complications associated with diabetes mellitus, such s diabetic cataracts, retinopathy and neuropathy, due to their inhibitory action on aldose reductase.
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