发明名称 |
COMPOSITIONS AND METHODS FOR LOOP DIURETICS WITH CONSISTENT BIOAVAILABILITY |
摘要 |
Diuretic bioactivity profiles of phase inversion micronized furosemide and furosemide co-precipitated with Eudragit L100, and mixtures of those formulations with stock furosemide, reduced or eliminated the rapid spike in diuresis associated with immediate release formulations and maintained cumulative urine output. Of the formulations tested, each of a mixture of micronized furosemide with stock furosemide, and Eudragit L100 polymer with stock furosemide demonstrated optimal diuretic bioactivity profiles in subjects. |
申请公布号 |
US2012053156(A1) |
申请公布日期 |
2012.03.01 |
申请号 |
US201113217764 |
申请日期 |
2011.08.25 |
申请人 |
MATHIOWITZ EDITH;LAULICHT BRYAN;BROWN UNIVERSITY |
发明人 |
MATHIOWITZ EDITH;LAULICHT BRYAN |
分类号 |
A61K31/635;A61K47/32;A61P1/16;A61P3/00;A61P5/00;A61P9/00;A61P13/12;C07D307/54 |
主分类号 |
A61K31/635 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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