发明名称 |
AN EPSTEIN-BARR-VIRUS VACCINE |
摘要 |
The present invention relates to a vaccine comprising a particle, said particle comprising (i) at least one Epstein-Barr virus (EBV) structural polypeptide, (ii) at least one EBV lytic polypeptide, (iii) membrane lipids, said particle being devoid of EBV DNA, wherein (a) the B-cell transformation capacity of one or more EBV polypeptides required for B-cell transformation as comprised in said particle is disabled while their immunogenicity is maintained; and/or (b) said particle is devoid of one or more EBV polypeptides required for B-cell transformation. Furthermore, the invention relates to a method for generating a particle, to a cell obtained in the method of the invention, a kit comprising the vaccine or the particle generated according to the method of the invention. Also, the invention relates to the use of the vaccine or the particle generated according to the method of the invention for generating CD8+ cells specific for an EBV antigen. |
申请公布号 |
WO2012025603(A1) |
申请公布日期 |
2012.03.01 |
申请号 |
WO2011EP64672 |
申请日期 |
2011.08.25 |
申请人 |
HELMHOLTZ ZENTRUM MUENCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH);LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;RUISS, ROMANA;REISBACH, GILBERT;HAMMERSCHMIDT, WOLFGANG;ZEIDLER, REINHARD |
发明人 |
RUISS, ROMANA;REISBACH, GILBERT;HAMMERSCHMIDT, WOLFGANG;ZEIDLER, REINHARD |
分类号 |
A61K39/245;C12N7/02;C12N7/04 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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