Enzymes conjugated to antiobodies via a PEG heterobifuctional linker
摘要
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
申请公布号
AU2006239315(B2)
申请公布日期
2012.03.01
申请号
AU20060239315
申请日期
2006.04.27
申请人
VENTANA MEDICAL SYSTEMS, INC.
发明人
LEFEVER, MARK;ASHWORTH-SHARPE, JULIA;WONG, JENNIFER;BIENIARZ, CHRISTOPHER;KERNAG, CASEY A.;KOSMEDER, JEROME W.