| 摘要 |
Bioactive implant for myocardial regeneration and ventricular chamber support, comprising:
I. an elastomeric microporous scaffold membrane comprising at least one non degradable synthetic polymer, one partially degradable synthetic polymer, and biomaterials of nanoporous or nanoscale fiber dimensions, said membrane having a porosity comprised between 70% and 90%, the pores being interconnected and having diameters comprised between 80 microns and 150 microns, wherein
a. Said non degradable synthetic polymer is selected from the group consisting of polyethylacrylate and polyethylacrylate copolymerized with a 10% wt or a 20% wt hydroxyethylacrylate comonomer; and
b. Said partially degradable synthetic polymer is selected from the group consisting of caprolactone 2-(methacryloyloxy)ethyl ester or of caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate in weight proportions of this last comonomer comprised between 30% and 80%,
wherein the percentage of non-degradable polymers versus degradable polymers is comprised between 10% wt and 90% wt and
II. a nanofiber hydrogel scaffold. |
