DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS
摘要
Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease.
申请公布号
EP2421954(A1)
申请公布日期
2012.02.29
申请号
EP20100714113
申请日期
2010.04.21
申请人
ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM
发明人
CHAMULEAU, ROBERT, ANTOINE, FRANCOIS, MARIE;HOEKSTRA, RUURDTJE;NIBOURG, GERARDUS, ADRIANUS, ANTONIUS