发明名称 |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
摘要 |
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification. |
申请公布号 |
US8124745(B2) |
申请公布日期 |
2012.02.28 |
申请号 |
US20100774566 |
申请日期 |
2010.05.05 |
申请人 |
ALLERSON CHARLES;BHAT BALKRISHEN;SWAYZE ERIC E.;PRAKASH THAZHA P.;ISIS PHARMACEUTICALS, INC |
发明人 |
ALLERSON CHARLES;BHAT BALKRISHEN;SWAYZE ERIC E.;PRAKASH THAZHA P. |
分类号 |
C07H19/00;C07H21/00;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
C07H19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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