COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE

摘要

A compound of formula A is proposedwhich can be named methyl 4-[(2-flouro-3{[(6-methyl(3-pyridile)amino]carbonylamino}-phenyl)methyl]piperazinecarboxylate or a pharmaceutically acceptable salt thereof comprising a pharmaceutically acceptable excipient, vehicle or adjuvant and a compound of formula A or a pharmaceutically acceptable salt. A method is also proposed for treating cardiac failure in mammals comprising administration a mammal a therapeutically acceptable amount of the compound of formula A or a pharmaceutically acceptable salt or a pharmaceutical composition comprising the compound of formula A or a pharmaceutically acceptable salt. Wherein the heart failure is a congestive heart failure, including a systolic heart failure.