METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY

摘要

Disclosed is the use of a Programmed Cell Death-1 (PD-1) inhibitor in the manufacture of a medicament formulated to treat a tumor in a subject, wherein said PD-1 inhibitor is an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-PD-L2 antibody, an anti-PD-1 RNAi, an anti-PD-Ll RNAi, an anti-PD-L2 RNAi, an anti-PD-I antisense RNA, an anti-PD-L1 antisense RNA, an anti-PD-L2 antisense RNA, a dominant negative PD-1 protein, a dominant negative PD-L1 protein, or a dominant negative PD-L2 protein, wherein said tumor is angioimmunoblastic lymphoma, or nodular lymphocyte predominant Hodgkin's lymphoma.