2-AMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

摘要

Disclosed are (2-aminopyridin-3-yl)(heteroaryl)methanone derivatives as represented by the general formula, wherein B is a monocyclic heteroaromatic ring, a 6,6 bicyclic heteroaromatic ring, or a 6,5 bicyclic heteroaromatic ring wherein B is optionally and independently substituted with R12' and independently optionally and independently substituted with one or more R12 groups in addition to R3; Z is O or S; R1 is hydrogen, halogen, cyano, nitro, or -T1-Q1; R2 is hydrogen, halogen, cyano, nitro or optionally and independently substituted alkyl; R3 is halogen, cyano, nitro, or -T2-Q2; and wherein the remaining substituents are as defined herein. Further disclosed is a composition which comprises a compound of pharmaceutically acceptable salt thereof as defined above, and a pharmaceutically acceptable carrier, adjuvant, or vehicle for treating or preventing a protein kinase-mediated condition and particularly a GSK 3 mediated condition such as diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, and rheumatoid arthritis.