发明名称 |
PHARMACEUTICAL COMPOSITIONS OF CONJUGATED ESTROGENS AND METHODS FOR THEIR USE |
摘要 |
This invention relates to novel pharmaceutical compositions containing conjugated estrogens for the treatment of peri-menopausal, menopausal and post-menopausal disorders in women. The novel pharmaceutical compositions comprise a carrier base material and conjugated estrogens formed into a solid unit dosage form possessing a regular incremental release of the medicament upon oral administration. Further, the invention comprises the combination of conjugated estrogens with progestogens in a solid, shaped dosage unit. Specifically, the invention comprises the use of an organic excipient such as high molecular weight hydroxyalkyl alkylcelluloses. The use of an organic excipient such as hydroxypropylmethylcellulose in a stable, solid dosage formulation containing either conjugated estrogens alone or in combination with a progestogen is described.
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申请公布号 |
WO9704752(A1) |
申请公布日期 |
1997.02.13 |
申请号 |
WO1996US11797 |
申请日期 |
1996.07.16 |
申请人 |
DURAMED PHARMACEUTICALS, INC. |
发明人 |
HUBER, HAROLD, E.;RYAN, MARY, K. |
分类号 |
A61K9/36;A61K9/20;A61K9/24;A61K9/28;A61K31/56;A61K31/565;A61K31/57;A61K47/38;A61P15/00;(IPC1-7):A61K9/36 |
主分类号 |
A61K9/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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