摘要 |
<p>Provided is a compound for inhibiting abnormal glucose intolerance and postprandial hyperglycemia in diabetic patients by inhibiting the activity of sodium-glucose transporter 1 (SGLT 1) and the absorption of glucose. Specifically provided are a 4-isopropylphenyl glucitol compound represented by formula (I) and a pharmaceutically acceptable salt of said compound. In the formula, R1 represents a hydrogen atom or an optionally substituted C1-4 alkyl group; R2 and R3 represent a hydrogen atom, methyl group, ethyl group or a hydroxymethyl group; R4 and R5 represent a hydrogen atom, a methyl group or a hydroxymethyl group; n is 0 or 1; R6 represents a hydrogen atom, an optionally substituted piperidyl group or an optionally substituted C1-6 alkyl group; R7 represents a hydrogen atom or a C1-4 alkyl group; W represents a single bond, a methylene group or a carbonyl group; and Y represents a C1-4 alkylene group or carbonyl group.</p> |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;KAKINUMA, HIROYUKI;KOBASHI, YOHEI;KAWAMURA, MADOKA;SHIOZAWA, FUMIYASU;IWATA, YUKI;KAWABE, KENICHI;KURODA, SHOICHI;HAMADA, MAKOTO |
发明人 |
KAKINUMA, HIROYUKI;KOBASHI, YOHEI;KAWAMURA, MADOKA;SHIOZAWA, FUMIYASU;IWATA, YUKI;KAWABE, KENICHI;KURODA, SHOICHI;HAMADA, MAKOTO |