发明名称 |
OLIGONUCLEOTIDE CHELATE COMPLEXES |
摘要 |
<p>The present disclosure describes the broadly active chelation of diverse divalent 2+ metal cations by any oligonucleotide (ON), regardless of size or modification. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.</p> |
申请公布号 |
WO2012021985(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
WO2011CA00956 |
申请日期 |
2011.08.18 |
申请人 |
REPLICOR INC.;VAILLANT, ANDREW;BAZINET, MICHEL |
发明人 |
VAILLANT, ANDREW;BAZINET, MICHEL |
分类号 |
A61K47/02;A61K31/7088;A61K31/712;A61K31/7125;A61K31/713;C07H21/00 |
主分类号 |
A61K47/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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