| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a dsRNA induced specific and non-specific immunity in crustaceans and other invertebrates, and biodelivery vehicles for use therein. <P>SOLUTION: The methods induce systemic, non-specific and/or sequence specific immune responses in invertebrates, preferably in crustaceans, by the administration of at least one dsRNA, and in the methods, the dsRNA confers immunity against a pathogen, or modulates expression of gene that affects growth, reproduction, and general health or "robustness". There are also provided methods for identifying invertebrate genes, e.g., crustacean genes, the expression of which is involved in the induction of non-specific (systemic) immune responses against pathogens. There are also provided preferred delivery systems and methods for stably administering at least one dsRNA to a crustacean whereby the dsRNA is administered via injection, immersion, in a feed or nutrient medium or, that expresses the dsRNA and is ingestible by the crustacean, e.g., a shrimp. <P>COPYRIGHT: (C)2012,JPO&INPIT |
