发明名称 |
Methods and compositions based on shiga toxin type 1 protein |
摘要 |
The invention is based on the discovery of the epitope in the StxI protein for the 13C4 antibody. The invention features non-full length Stxl polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-StxI antibodies specific for the 13C4 epitope of the Stxl protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 13C4 epitope or with an anti-StxI antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stxl in a sample using the antibodies developed using the methods of the invention. |
申请公布号 |
EP2420246(A1) |
申请公布日期 |
2012.02.22 |
申请号 |
EP20110179552 |
申请日期 |
2007.04.20 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. |
发明人 |
SMITH, MICHAEL;MELTON-CELSA, ANGELA;O'BRIEN, ALISON |
分类号 |
A61K39/00;A61K39/108;A61K39/395;C07K14/245;C07K16/12 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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