PYRAZINE CARBOXAMIDES AS INHIBITORS OF DGAT1.

摘要

DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, r is 0 or 1 and X₁ is linear (1-3C)alkyl; q is 0 or 1 and X₁ is fluoro, chloro or (1-3C)alkyl; Y₁ is selected from fluoro, chloro, bromo, cyano, (1-3C)alkyl and (1-2C)alkoxy; n is 0, 1 or 2 and Y₂ is fluoro, chloro or (1-3C)alkyl; p is 0, 1 or 2 and Y₃ is (1-3C)alkyl or forms a (3-5C)cycloalkyl ring; Z is carboxy or - CONHSO₂ Me or –CONRbRc wherein Rb and Rc are independently selected, for example, from hydrogen and (1-4C)alkyl or Rb and Rc are linked so as to form a morpholine ring or a (4-6C)heterocyclic ring and when Z is –CONRbRc the Rb and Rc groups may be optionally substituted by carboxy.