| 摘要 |
Implantable medical devices, such as catheters, which comprise a calixarene-derived coating that resists adhesion and/or colonisation of bacteria, the calixarene being bonded to the surface of the device via one or more surface linker groups (preferably derived from acid chloride, chloroformate or silane functional groups) on the rim of the calixarene and comprising on the opposing rim one or more polyethylene glycol, polypropylene glycol or polytrimethylene glycol groups, or a mixture thereof; the glycol groups being attached to the calixarene via C3-16alkylene spacer groups; the glycol groups being either attached directly to the alkylene spacer group or via another linking group (such as a carbonate, carbamate, urea, phosphate or triazole group); said glycol groups having 2-250 repeating glycol units and being optionally terminated by hydrogen or C1â 4alkyl. The most preferred calixarene is of the form: The calixarene is preferably bonded to a device with a silicone surface. Calixarene-derived coating materials, intermediates useful in their manufacture, and to processes for the coating of the implantable devices are also claimed. |
