发明名称 |
INDUCTION OF AN IMMUNE RESPONSE AGAINST DENGUE VIRUS USING THE PRIME-BOOST APPROACH |
摘要 |
The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprises administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins. |
申请公布号 |
US2012039937(A1) |
申请公布日期 |
2012.02.16 |
申请号 |
US201113281473 |
申请日期 |
2011.10.26 |
申请人 |
SIMMONS MONIKA;PORTER KEVIN R.;RAVIPRAKASH KANAKATTE;SUN WELLINGTON |
发明人 |
SIMMONS MONIKA;PORTER KEVIN R.;RAVIPRAKASH KANAKATTE;SUN WELLINGTON |
分类号 |
A61K39/12;A61P31/14;A61P37/04 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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