摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel compound which can concertedly inhibit ectoenzymes dipeptidyl peptidase IV (DPIV) and alanyl aminopeptidase (APN) cooperatively. <P>SOLUTION: The compound is a compound of formula (I) or an acid addition salt with an organic acid and/or inorganic acid. (In the formula, residues R1, R2, R3 and R4 may be the same or different, -H, >C(=O), -C(=O)O- and the like; E represents -O-, -S-, -NH- and the like; Y represents -O-, -NH- and the like; B represents an alkyl substituted group or an alkoxy substituted group having an aryl group or a heterocyclic ring; and C represents a substitution group having amide bond or sulfonamide bond). <P>COPYRIGHT: (C)2012,JPO&INPIT |