| 发明名称 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOPOIETIN 1 AND 2 AND THEIR RECEPTOR TIE2 |
| 摘要 |
RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2 mediated angiogenesis, such as inflammatory and autoimmune diseases, diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. |
| 申请公布号 |
US2012039986(A1) |
申请公布日期 |
2012.02.16 |
| 申请号 |
US201113163806 |
申请日期 |
2011.06.20 |
| 申请人 |
REICH SAMUEL JOTHAM;TOLENTINO MICHAEL J.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
REICH SAMUEL JOTHAM;TOLENTINO MICHAEL J. |
| 分类号 |
A61K31/713;A61K9/127;A61K31/704;A61K33/24;A61K39/395;A61K48/00;A61P3/10;A61P27/02;A61P35/00;C07H21/02;C07H21/04;C12N;C12N15/113;C12N15/63;C12Q1/68 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
